Polyurethanes anoshandiswa zvakanyanya mu biomedical application senge ganda rekugadzira, mubhedha wemuchipatara, dialysis machubhu, pacemaker components, catheters, uye machira ekuvhiya.Iyo biocompatibility, michina zvivakwa, uye mutengo wakaderera ndizvo zvinhu zvikuru zvekubudirira kwepolyurethanes mundima yekurapa.

Kuvandudzwa kwezvipimo zvinowanzoda huwandu hwepamusoro hwezvikamu zvebio-based, nokuti muviri unozviramba zvishoma.Kana iri polyurethanes, iyo biocomponent inogona kusiyana kubva pa30 kusvika 70%, izvo zvinogadzira nzvimbo yakakura yekushandiswa munzvimbo dzakadai (2)Iyo biobased polyurethanes iri kuwedzera chikamu chemusika uye inotarisirwa kusvika pamadhora makumi mana nemaviri kusvika 2022, iri minuscule percent yemusika wese we polyurethane (pasi pe0.1%).Zvakadaro, inzvimbo inovimbisa, uye tsvakiridzo yakadzama iri kuenderera mberi maererano nekushandiswa kwezvimwe zvinhu zvebiobased mu polyurethanes.Kuvandudzwa kunodiwa mumidziyo yebiobased polyurethanes kuti ienderane nezvinodiwa zviripo, kuitira kukwirisa mari.

Biobased crystalline polyurethane yakagadzirwa kuburikidza nekuita kwePCL, HMDI, uye mvura yakaita basa reketani yekuwedzera (33)Miedzo yekudzikisira yakaitwa kuti iongorore kugadzikana kwebiopolyurethane mumvura inofananidzwa nemuviri, senge phosphate-buffered saline solution.Iko kushanduka

mune zvinopisa, zvemagetsi, uye zvenyama zvakaongororwa uye zvichienzaniswa nezvakaenzana

polyurethane inowanikwa kuburikidza nekushandisa ethylene glycol secheni inotambanudza panzvimbo yemvura.Mhedzisiro yacho yakaratidza kuti iyo polyurethane yakawanikwa ichishandisa mvura secheni yekuwedzera yakaratidza zvivakwa zviri nani nekufamba kwenguva zvichienzaniswa neayo petrochemical yakaenzana.Izvi hazvingodziki zvakanyanya

mutengo wekuita, asi inopawo nzira iri nyore yekuwana kukosha-yakawedzerwa mishonga yekurapa iyo yakakodzera majoini endoprostheses (33)Izvi zvakateverwa neimwe nzira yakavakirwa pane iyi pfungwa, iyo yakagadzira biopolyurethane urea nekushandisa rapeseed mafuta-based polyol, PCL, HMDI, uye mvura secheni extender (6)Kuwedzera nzvimbo yepamusoro, sodium chlorine yakashandiswa kuvandudza porosity yemapolymer akagadzirirwa.Iyo yakagadzirwa polymer yakashandiswa se scaffold nekuda kweiyo porous dhizaini yekukurudzira kukura kwesero rebhonzo tishu.Nemigumisiro yakafanana kana ichienzaniswa

kumuenzaniso wekare, iyo polyurethane iyo yakaratidzwa kune yakafananidzirwa yemvura yemuviri yakaratidza kugadzikana kwepamusoro, ichipa sarudzo inogoneka kune scaffold application.Polyurethane ionomers imwe inonakidza kirasi yemapolymers anoshandiswa kune biomedical application, semhedzisiro yebiocompatibility uye kudyidzana kwakaringana nemhoteredzo yemuviri.Polyurethane ionomers inogona kushandiswa sechubhu zvikamu zvepacemaker uye hemodialysis (34, 35).

Kuvandudzwa kweiyo inoshanda dhizaini system inzvimbo yakakosha yekutsvagisa iyo parizvino yakatarisana nekutsvaga nzira dzekurwisa gomarara.An amphiphilic nanoparticle ye polyurethane yakavakirwa paL-lysine yakagadzirirwa kushandiswa kwekushandisa zvinodhaka (36)Nanocarrier iyi

yakanyatso kutakurwa ne doxorubicin, inova inoshanda zvinodhaka kurapa kenza maseru (Mufananidzo 16).Izvo zvikamu zvehydrophobic zve polyurethane zvakapindirana nemushonga, uye zvikamu zve hydrophilic zvakapindirana nemasero.Iyi sisitimu yakagadzira core-shell chimiro kuburikidza ne-self-assembly

michina uye yakakwanisa kuendesa mishonga nenzira mbiri.Chekutanga, mhinduro yekupisa ye nanoparticle yakaita sechinhu chinokonzeresa kuburitsa mushonga patembiricha yekenza (~ 41-43 ° C), inova mhinduro yekunze.Chechipiri, zvikamu zvealiphatic zve polyurethane zvakatambura

enzymatic biodegradation nekuita kwe lysosomes, zvichibvumira doxorubicin kuburitswa mukati mekenza cell;iyi intracellular response.Anopfuura makumi mapfumbamwe muzana emasero egomarara rezamu akaurayiwa, nepo yakaderera cytotoxicity yaichengeterwa maseru ane hutano.

Mufananidzo 16. Yakazara chirongwa cheiyo dhizaini yekuburitsa system yakavakirwa pane amphiphilic polyurethane nanoparticle

kunanga masero egomarara. Yakadhindwa nemvumo kubva kune referensi(36).Copyright 2019 American Chemical

Society.

Declaration:Chinyorwa chakatorwa kubvaNhanganyaya kune Polyurethane ChemistryFelipe M. de Souza, 1 Pawan K. Kahol, 2 naRam K.Gupta *,1 .Chete chekukurukurirana uye kudzidza, usaite zvimwe zvekutengesa zvinangwa, hazvimiriri maonero nemafungiro ekambani, kana iwe uchida kudhindazve, ndapota taura nemunyori wepakutanga, kana paine kukanganisa, ndapota taura nesu nekukurumidza kuti tiite delete processing.